Student : Oliwier Krajweski
Piezo1 is an ion channel that responds to mechanical cues and plays a regulatory role in various nervous system processes, including axonal growth, glial cell activation and oligodendrocyte progenitor cell (OPC) biology. The primary objective of the project is to explore the impact of pharmacological activation and inhibition of Piezo1 on oligodendrocyte differentiation and normal myelin development in the central nervous system. To achieve this goal, we are using primary cell cultures to investigate how Piezo1 influences the differentiation of OPCs into mature oligodendrocytes. In the organotypic cerebellar slice model, we are studying the impact of Piezo1 on myelination in a more complex environment resembling the central nervous system. By combining these approaches, we will gain insights into the relationship between Piezo1 and myelin development as well as its potential to rebuild myelin under pathophysiological conditions. The findings from this study may contribute to our understanding of myelin formation and could potentially lead to the development of new therapeutic strategies for demyelinating diseases.
This project is being carried out in partnership with Dr. Maria Velasco-Estevez, Spanish National Cancer Research Center (Centro Nacional de Investigaciones Oncológicas, CNIO), Madrid, Spain
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