EBI2 receptor as a new myelin repair therapy in multiple sclerosis

In this project, we use a novel bioactive fluoro analogue of 7α,25OHC in the cuprizone model of MS to investigate its myelination-enhancing properties. We will also investigate the molecular and cellular mechanisms behind 7α,25OHC-induced remyelination in the organotypic cerebellar slice model and the effects of increased EBI2/7α,25OHC signalling on the function of primary oligodendrocyte progenitor cells, astrocytes and microglia using EBI2 KO mice.

Come back to Remyelination